ETV6/RUNX1 FUSION GENE ABROGATION DECREASES THE ONCOGENICITY OF TUMOUR CELLS IN A PRECLINICAL MODEL OF ACUTE LYMPHOBLASTIC LEUKAEMIA

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia.The implication of the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Methods: Generation of

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Codeveloping a community-based, peer-led psychosocial support intervention to reduce stigma and depression among people with tuberculosis and their households in Indonesia: a mixed-methods participatory action study

Abstract pull sandro outlet Evidence relating to peer support and community-based psychological and social (psychosocial) interventions to reduce stigma and depression among people with tuberculosis (TB) and their households is limited.This study aimed to engage with multisectoral stakeholders in Indonesia to co-develop a peer-led, community-based

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LEGAL ASPECTS OF DIGITAL BANKING

The rapid development of digital banking has fundamentally transformed the capabilities of the financial sector, offering a range of new opportunities and challenges.This paper explores the legal aspects of the transformation of the financial sector through digital banking.It analyzes the regulatory framework that impacts the development and implem

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Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages

BackgroundMelanoma has the highest mortality rate among all the types of skin cancer.In melanoma, M2-like tumor-associated macrophages (TAMs) are associated with the invasiveness of tumor cells and a poor prognosis.Hence, the depletion or reduction of M2-TAMs is a therapeutic strategy for the inhibition of tumor progression.The aim of this study bi

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